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彭斌

彭斌 副教授

细胞与医学遗传学系

基础医学院

binpeng@macaubetzx.com

(1)DNA损伤/DNA复制胁迫应答与肿瘤等疾病的发生发展的分子机制
(2)靶向基因组稳定性抗癌先导化合物的筛选和开发

彭斌,博士,深圳大学长聘副教授,特聘研究员,博士生导师,深圳市高层次人才。致力于基因组不稳定性与人类疾病(如肿瘤、先天性小头畸形)方面的研究,侧重于蛋白翻译后修饰调控DNA损伤/DNA复制胁迫应答的分子机制,并聚焦靶向基因组稳定性抗癌先导化合物的筛选和开发。在国际主流杂志PNAS, EMBO J, Nucleic Acids ReseLife, iScience, J Med Chem, J Biol Chem和Eur J Med Chem等发表SCI 论文20余篇。主持国家重点研发计划子课题;国家自然科学基金面上、青年项目;广东省自然科学基金青年提升、面上项目和深圳市科技计划基础研究项目等8个科研基金。参与国家自然科学基金重大项目、重点项目及国际合作等。

主持的代表性科研项目:

(1)国家重点研发计划子课题,复制压力和损伤应答异常导致肿瘤发生的机制及治疗策略,201.5万元, 2022.12-2027.11;

(2)国家自然科学基金,面上项目,单链DNA结合蛋白RPA32的棕榈酰化修饰调控复制胁迫应答的机制研究,50万元, 2024.01-2027.12;

(3)国家自然科学基金,青年项目,在DNA损伤应答中Polo样激酶1(PLK1)活性调控的分子机制,25万元, 2019.01-2021.12;

(4)广东省自然科学基金,青年提升项目,复制蛋白RPA32的棕榈酰化修饰调控复制压力下ATR-CHK1激活的机制研究,30万元, 2024.01-2026.12;

(5)广东省自然科学基金,面上项目,先天性小头畸形相关蛋白ASPM促进复制压力下 ATR-CHK1的激活的机制研究,10万元, 2019.10-2022.09。

代表性学术论文(#共同第一作者,*通讯作者):

(1) Wu, X#. Xu, S.# Wang, P. Wang, Z. Q. Chen, H. Xu, X.* Peng, B.* (2022). ASPM promotes ATR-CHK1 activation and stabilizes stalled replication forks in response to replication stress. Proc Natl Acad Sci U S A., e2203783119.

(2) Peng, B.*, R. Shi, J. Bian, Y. Li, P. Wang, H. Wang, J. Liao, W. G. Zhu and X. Xu* (2021). "PARP1 and CHK1 coordinate PLK1 enzymatic activity during the DNA damage response to promote homologous recombination-mediated repair." Nucleic Acids Res 49(13): 7554-7570. 

(3) Xuefei Zhu#*, Congwen Gao#, Bin Peng#, Jingwei Xue, Donghui Xia, Liu Yang, Jiexiang Zhang, Xinrui Gao, Yilin Hu, Shixian Lin, Peng Gong*, Xingzhi Xu* (2024). FOXP1 phosphorylation antagonizes its O-GlcNAcylation in regulating ATR activation in response to replication stress. EMBO J. 44(2):457-483.

(4) Peng, B., J. Wang, Y. Hu, H. Zhao, W. Hou, H. Zhao, H. Wang, J. Liao and X. Xu* (2015). "Modulation of LSD1 phosphorylation by CK2/WIP1 regulates RNF168-dependent 53BP1 recruitment in response to DNA damage." Nucleic Acids Res 43(12): 5936-5947.

(5) Peng, B.#, R. Shi#, W. Jiang#, Y. H. Ding, M. Q. Dong, W. G. Zhu and X. Xu* (2017). "Phosphorylation of LSD1 by PLK1 promotes its chromatin release during mitosis." Cell Biosci 7: 15.

(6) Meng, F.#, M. Qian#, B. Peng#, L. Peng, X. Wang, K. Zheng, Z. Liu, X. Tang, S. Zhang, S. Sun, X. Cao, Q. Pang, B. Zhao, W. Ma, Z. Songyang, B. Xu, W. G. Zhu, X. Xu* and B. Liu* (2020). "Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice." eLife 9.

(7) Xu, S.#, X. Wu#, P. Wang, S. L. Cao*, B. Peng* and X. Xu* (2021). "ASPM promotes homologous recombination-mediated DNA repair by safeguarding BRCA1 stability." iScience 24(6): 102534.

(8) Li, J.#, Liu, X.#, Peng, B#., Feng, T., Zhou, W., Meng, L., Zhao, S., Zheng, X., Wu, C., Wu, S. et al. (2023) O-GlcNAc has crosstalk with ADP-ribosylation via PARG. J Biol Chem, 105354.

(9) S. Yan#, B. Peng#, S. Kan#, G. Shao, Z. Xiahou, X. Tang, Y.X. Chen, M.Q. Dong, X. Liu*, X. Xu*, J. Li*, Polo-like kinase 1 (PLK1) O-GlcNAcylation is essential for dividing mammalian cells and inhibits uterine carcinoma, J Biol Chem, (2023) 10288.

(10) Han, X.#, B. Peng#, B. B. Xiao, C. Sheng-Li*, C. R. Yang, W. Z. Wang, F. C. Wang, H. Y. Li, X. L. Yuan, R. Shi, J. Liao, H. Wang, J. Li and X. Xu* (2019). "Synthesis and evaluation of chalcone analogues containing a 4-oxoquinazolin-2-yl group as potential anti-tumor agents." Eur J Med Chem 162: 586-601.

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